Comparative mutagenicities of N6-methoxy-2,6-diaminopurine and N6- methoxyaminopurine 2'-deoxyribonucleosides and their 5'-triphosphates
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چکیده
منابع مشابه
Dual Fluorescence from N6,N6-Dimethyladenosine
The adenosine derivative N6,N6-dimethyladenosine (DMA) shows dual fluorescence in solvents of different polarity. In addition to the “normal” fluorescence at 330 nm, another band is observed at 500 nm. The long wavelength emission dominates in aprotic solvents but is dynamically quenched by protic solvents. Steady-state and lifetime measurements show that the emissions originate from two excite...
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The Human Genome Project has facilitated the sequencing of many species, yet the current Sanger method is too expensive, labor intensive and time consuming to accomplish medical resequencing of human genomes en masse. Of the 'next-generation' technologies, cyclic reversible termination (CRT) is a promising method with the goal of producing accurate sequence information at a fraction of the cost...
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High hydrostatic pressure affects in various ways the reactivity and the stability of biogenic macromolecules [ 11. Pressures of several hundred bars reduce or increase enzymic activity [2-41. Proteins are usually irreversibly denaturated by pressures in excess of 1 kbar. On the other hand, calf thymus DNA is stabilized by increased pressure [5]. In general, an increase in pressure shifts an eq...
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Ribosomal subunits from the chloroplasts of Alaskan peas have been studied by immunoelectronmicroscopy. Electron micrographs of negatively stained small and large ribosomal subunits show particles of similar size and in the same characteristic projections described for the ribosomal subunits of Escherichia coli (Lake, J. A. (1976) J. Mol. Biol. 105, 131-159), although minor structural differenc...
متن کاملFTO-Mediated Formation of N6-Hydroxymethyladenosine and N6-Formyladenosine in Mammalian RNA
N(6)-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N(6)-hydroxymethyladenosine (hm(6)A) and N(6)-formyladenosine (f(6)A), in mammalian messenger RNA. We show that Fe(II)- and α-ketoglutarate-dependent fat mass and obesity-associated (FTO) protein oxidize ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1998
ISSN: 1362-4962
DOI: 10.1093/nar/26.5.1144